About us

The Moon (Sleep) Lab for Artificial Intelligence Technology (MoonLAIT), led by Yue Leng, PhD, is not just another research lab; it is where data, sleep science, and innovation come together to redefine our understanding of neurodegenerative diseases like Alzheimer’s and Parkinson’s. We explore the untapped frontiers of sleep research, employing big data and machine learning, and aim to be trailblazers in early detection and intervention strategies for neurodegenerative diseases.

Check out our ongoing research projects!

Happening now at MoonLAIT

We are hiring! 

We are looking for highly motivated individuals to join our team. We are considering applications for postdoctoral scholars and data analysts. Click here to learn how to apply!

New precision medicine grant

We are excited to announce that Dr. Leng has received a new award from the Marcus Program in Precision Medicine Innovation (MPPMI) for the GenSleep project, which focuses on gene-environment interactions and neurodegenerative disease trajectories. Click here to learn more about the project.

Recent publications 

2026:

Machine learning–based sleep electroencephalographic brain age index and dementia risk: an individual participant data meta-analysis

JAMA Network Open (2026)
Sun HMilton SFang YTaha HBShiju S, Thomas RJ, Ganglberger W, Pase MP, Hughes T, Purcell S, Redline S, Stone KL, Yaffe K, Westover MB, Leng Y.

Keeping Time With the 24-Hour Brain: What Rest-Activity Rhythms Reveal About Dementia Risk

Neurology (2026)

Fang Y, Leng Y.

2025:

Self-perceived life course sleep duration trajectories and risk and age at onset of Parkinson's disease

NPJ Parkinsons Disease (2025)

Fang Y, Yaffe K, Little S, Tanner C, Leng Y.

 

Racial and Ethnic and Sex Differences in At-Home Estimates of Obstructive Sleep Apnea Parameters among Diverse Adults

 

Annals of the American Thoracic Society (2025)

Leng Y, Cavaillès C, Peltz C, O'Bryant S, Redline S, Yaffe K.

 

Five-Year Changes in 24-Hour Sleep-Wake Activity and Dementia Risk in Oldest Old Women

 

Neurology (2025)

Milton S, Cavaillès C, Ancoli-Israel S, Stone K, Yaffe K, Leng Y.

 

Association of rapid eye movement sleep latency with multimodal biomarkers of Alzheimer's disease

 

Alzheimer's & Dementia​ (2025)

Jin J, Chen J, Cavaillès C, Yaffe K, Winer J, Stankeviciute L, Lucey BP, Zhou X, Gao S, Peng D, Leng Y.